All Publications

Mitochondrial morphology controls fatty acid utilization by changing CPT1 sensitivity to malonyl-CoA.

Ngo J, Choi DW, Stanley IA, Stiles L, Molina AJA, Chen PH, Lako A, Sung ICH, Goswami R, Kim MY, Miller N, Baghdasarian S, Kim-Vasquez D, Jones AE, Roach B, Gutierrez V, Erion K, Divakaruni AS, Liesa M, Danial NN*, Shirihai OS. EMBO J. 2023 Jun 1;42(11):e111901. doi: 10.15252/embj.2022111901. Epub 2023 Mar 14. PMID: 36917141. *Co-corresponding Author

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MCL-1 is a master regulator of cancer dependency on fatty acid oxidation.

Prew MS, Adhikary U, Choi DW, Portero EP, Paulo JA, Gowda P, Budhraja A, Opferman JT, Gygi SP, Danial NN, Walensky LD. Cell Rep. 2022 Oct 4;41(1):111445. doi: 10.1016/j.celrep.2022.111445. PMID: 36198266.

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Mitochondrial pyruvate supports lymphoma proliferation by fueling a glutamate pyruvate transaminase 2-dependent glutaminolysis pathway.

Wei P, Bott AJ, Cluntun AA, Morgan JT, Cunningham CN, Schell JC, Ouyang Y, Ficarro SB, Marto JA, Danial NN, DeBerardinis RJ, Rutter J. Sci Adv. 2022 Sep 30;8(39):eabq0117. doi: 10.1126/sciadv.abq0117. Epub 2022 Sep 30. PMID: 36179030.

 

Glucose metabolism and pyruvate carboxylase enhance glutathione synthesis and restrict oxidative stress in pancreatic islets.

Fu A, van Rooyen L, Evans L, Armstrong N, Avizonis D, Kin T, Bird GH, Reddy A, Chouchani ET, Liesa-Roig M, Walensky LD, Shapiro AMJ, Danial NN. Cell Rep. 2021 Nov 23;37(8):110037. doi: 10.1016/j.celrep.2021.110037. PMID: 34818536.

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More Metabolism!

Olzmann JA, Fendt SM, Shah YM, Vousden K, Chandel N, Horng T, Danial N, Tu B, Christofk H, Vander Heiden MG, Wellen K. Mol Cell. 2021 Sep 16;81(18):3659-3664. doi: 10.1016/j.molcel.2021.08.040. PMID: 34547228.

 

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control oflocalized translation in mouse and human models.
Githaka JM, Tripathi N, Kirschenman R, Patel N, Pandya V, Kramer DA, Montpetit R, Zhu LF, Sonenberg N, Fahlman RP, Danial NN, Underhill DA, Goping IS. Nat Commun. 2021 May 19;12(1):2939. doi: 10.1038/s41467-021-23269-8. PMID: 34011960; PMCID: PMC8134504.

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UCP1 governs liver extracellular succinate and inflammatory pathogenesis.
Mills EL, Harmon C, Jedrychowski MP, Xiao H, Garrity R, Tran NV, Bradshaw GA, Fu A, Szpyt J, Reddy A, Prendeville H, Danial NN, Gygi SP, Lynch L, Chouchani ET. Nat Metab. 2021 May;3(5):604-617. doi: 10.1038/s42255-021-00389-5. Epub 2021 May 17. PMID: 34002097.

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Development of a novel fluorescent biosensor for dynamic monitoring of metabolic methionine redox status in cells and tissues.
Choi DW, Roh YJ, Kim S, Lee HM, Kim M, Shin D, Park JH, Cho Y, Park HH, Ok YS, Kang D, Kim JH, Tarrago L, Danial NN, Gladyshev VN, Min PK, Lee BC. Biosens Bioelectron. 2021 Apr 15;178:113031. doi: 10.1016/j.bios.2021.113031. Epub 2021 Jan 29. PMID: 33571808.

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CRISPR-engineered human brown-like adipocytes prevent diet-induced obesity and ameliorate metabolic syndrome in mice.

Wang CH, Lundh M, Fu A, Kriszt R, Huang TL, Lynes MD, Leiria LO, Shamsi F, Darcy J, Greenwood BP, Narain NR, Tolstikov V, Smith KL, Emanuelli B, Chang YT, Hagen S, Danial NN, Kiebish MA, Tseng YH. Sci Transl Med. 2020 Aug 26;12(558):eaaz8664. doi: 10.1126/scitranslmed.aaz8664. PMID: 32848096; PMCID: PMC7704293.

 

Glucose-dependent partitioning of arginine to the urea cycle protects B-cells from inflammation.

Fu A, Alvarez-Perez JC, Avizonis D, Kin T, Ficarro SB, Choi DW, Karakose E, Badur MG, Evans L, Rosselot C, Bridon G, Bird GH, Seo HS, Dhe-Paganon S, Kamphorst JJ, Stewart AF, James Shapiro AM, Marto JA, Walensky LD, Jones RG,
Garcia-Ocana A, Danial NN. Nat Metab. 2020 May;2(5):432-446. doi: 10.1038/s42255-020-0199-4. Epub 2020 May 11. PMID: 32694660; PMCID: PMC7568475.

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Hydrocarbon-Stitched Peptide Agonists of Glucagon-Like Peptide-1 Receptor.
Bird GH, Fu A, Escudero S, Godes M, Opoku-Nsiah K, Wales TE, Cameron MD, Engen JR, Danial NN, Walensky LD. ACS Chem Biol. 2020 Jun 19;15(6):1340-1348. doi: 10.1021/acschembio.0c00308. Epub 2020 May 27. PMID: 32348108; PMCID:
PMC7366314.

 

Partitioning of MLX-Family Transcription Factors to Lipid Droplets Regulates Metabolic Gene Expression.

Mejhert N, Kuruvilla L, Gabriel KR, Elliott SD, Guie MA, Wang H, Lai ZW, Lane EA, Christiano R, Danial NN, Farese RV Jr, Walther TC. Mol Cell. 2020 Mar 19;77(6):1251-1264.e9. doi: 10.1016/j.molcel.2020.01.014. Epub 2020 Feb 4.PMID: 32023484 

 

Fibroblastic reticular cells enhance T cell metabolism and survival via epigenetic remodeling.
Brown FD, Sen DR, LaFleur MW, Godec J, Lukacs-Kornek V, Schildberg FA, Kim HJ, Yates KB, Ricoult SJH, Bi K, Trombley JD, Kapoor VN, Stanley IA, Cremasco V, Danial NN, Manning BD, Sharpe AH, Haining WN, Turley SJ. Nat
Immunol. 2019 Dec;20(12):1668-1680. doi: 10.1038/s41590-019-0515-x. Epub 2019 Oct 21. PMID: 31636464; PMCID: PMC7464610.

 

HCF-1 Regulates De Novo Lipogenesis through a Nutrient-Sensitive Complex with ChREBP.
Lane EA, Choi DW, Garcia-Haro L, Levine ZG, Tedoldi M, Walker S, Danial NN. Mol Cell. 2019 Jul 25;75(2):357-371.e7. doi:

10.1016/j.molcel.2019.05.019. Epub 2019 Jun 18. PMID: 31227231; PMCID: PMC6744259.

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Grasping for aspartate in tum our metabolism.

Fu A, Danial NN. Nat Cell Biol. 2018 Jul;20(7):738-739. doi: 10.1038/s41556-018-0137-9. PMID: 29941932.

 

BAD and KATP channels regulate neuron excitability and epilepti form activity.

Martínez-François JR, Fernández-Agüera MC, Nathwani N, Lahmann C, Burnham VL, Danial NN*, Yellen G.Elife. 2018 Jan 25;7:e32721. doi: 10.7554/eLife.32721. PMID: 29368690; PMCID: PMC5785210. *Co-corresponding Author

 

BAD knockout provides metabolic seizure resistance in a genetic model of epilepsy with sudden unexplained death in epilepsy.

Foley J, Burnham V, Tedoldi M, Danial NN, Yellen G. Epilepsia. 2018 Jan; 59(1):e1-e4. doi: 10.1111/epi.13960. Epub 2017 Nov 23. PMID: 29171006; PMCID: PMC5760331.

 

Differential contribution of the mitochondrial translation pathway to the survival of diffuse large B-cell lymphoma subsets.

Norberg E, Lako A, Chen PH, Stanley IA, Zhou F, Ficarro SB, Chapuy B, Chen L, Rodig S, Shin D, Choi DW, Lee S, Shipp MA, Marto JA, Danial NN. Cell Death Differ. 2017 Feb;24(2):251-262. doi: 10.1038/cdd.2016.116. Epub 2016 Oct 21. PMID: 27768122; PMCID: PMC5299709.

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Regulation of mitochondrial nutrient and energy metabolism by BCL-2 family proteins.

Giménez-Cassina A, Danial NN. Trends Endocrinol Metab. 2015 Apr;26(4):165-75. doi: 10.1016/j.tem.2015.02.004. Epub 2015 Mar 5. PMID: 25748272; PMCID: PMC4380665.

 

Phospho-BAD BH3 mimicry protects β cells and restores functional B-cell mass in diabetes.

Ljubicic S, Polak K, Fu A, Wiwczar J, Szlyk B, Chang Y, Alvarez-Perez JC, Bird GH, Walensky LD, Garcia-Ocaña A, Danial NN. Cell Rep. 2015 Feb 3;10(4):497-504. doi: 10.1016/j.celrep.2014.12.056. Epub 2015 Jan 29. PMID: 25640178; PMCID: PMC4991214.

 

Measurement of mitochondrial oxygen consumption rates in mouse primary neurons and astrocytes.

Ribeiro SM, Giménez-Cassina A, Danial NN. Methods Mol Biol. 2015;1241:59-69. doi: 10.1007/978-1-4939-1875-1_6. PMID: 25308488.

 

Adipsin is an adipokine that improves β cell function in diabetes.

Lo JC, Ljubicic S, Leibiger B, Kern M, Leibiger IB, Moede T, Kelly ME, Chatterjee Bhowmick D, Murano I, Cohen P, Banks AS, Khandekar MJ, Dietrich A, Flier JS, Cinti S, Blüher M, Danial NN, Berggren PO, Spiegelman BM. Cell. 2014 Jul
3;158(1):41-53. doi: 10.1016/j.cell.2014.06.005. PMID: 24995977; PMCID: PMC4128197.

 

Inhibiting Tankyrases sensitizes KRAS-mutant cancer cells to MEK inhibitors via FGFR2 feedback signaling.

Schoumacher M, Hurov KE, Lehár J, Yan-Neale Y, Mishina Y, Sonkin D, Korn JM, Flemming D, Jones MD, Antonakos B, Cooke VG, Steiger J, Ledell J, Stump MD, Sellers WR, Danial NN, Shao W. Cancer Res. 2014 Jun 15;74(12):3294-305. doi: 10.1158/0008-5472.CAN-14-0138-T. Epub 2014 Apr 18. PMID: 24747911.

 

D-2-hydroxyglutarate produced by mutant IDH2 causes cardiomyopathy and neuro degeneration in mice.

Akbay EA, Moslehi J, Christensen CL, Saha S, Tchaicha JH, Ramkissoon SH, Stewart KM, Carretero J, Kikuchi E, Zhang H, Cohoon TJ, Murray S, Liu W, Uno K, Fisch S, Jones K, Gurumurthy S, Gliser C, Choe S, Keenan M, Son J, Stanley I,
Losman JA, Padera R, Bronson RT, Asara JM, Abdel-Wahab O, Amrein PC, Fathi AT, Danial NN, Kimmelman AC, Kung AL, Ligon KL, Yen KE, Kaelin WG Jr, Bardeesy N, Wong KK. Genes Dev. 2014 Mar 1;28(5):479-90. doi: 10.1101/gad.231233.113. PMID: 24589777; PMCID: PMC3950345.

 

Regulation of hepatic energy metabolism and gluconeogenesis by BAD.

Giménez-Cassina A, Garcia-Haro L, Choi CS, Osundiji MA, Lane EA, Huang H, Yildirim MA, Szlyk B, Fisher JK, Polak K, Patton E, Wiwczar J, Godes M, Lee DH, Robertson K, Kim S, Kulkarni A, Distefano A, Samuel V, Cline G, Kim YB, Shulman
GI, Danial NN. Cell Metab. 2014 Feb 4;19(2):272-84. doi: 10.1016/j.cmet.2013.12.001. PMID: 24506868; PMCID: PMC3971904.

 

A phospho-BAD BH3 helix activates glucokinase by a mechanism distinct from that of allosteric activators.

Szlyk B, Braun CR, Ljubicic S, Patton E, Bird GH, Osundiji MA, Matschinsky FM, Walensky LD, Danial NN. Nat Struct Mol Biol. 2014 Jan;21(1):36-42. doi: 10.1038/nsmb.2717. Epub 2013 Dec 8. PMID: 24317490; PMCID: PMC4084830.

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Changing appetites: the adaptive advantages of fuel choice.

Stanley IA, Ribeiro SM, Giménez-Cassina A, Norberg E, Danial NN. Trends Cell Biol. 2014 Feb;24(2):118-27. doi: 10.1016/j.tcb.2013.07.010. Epub 2013 Sep 7. PMID: 24018218; PMCID: PMC3946676.

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How does the ketogenic diet work? Four potential mechanisms.

Danial NN, Hartman AL, Stafstrom CE, Thio LL. J Child Neurol. 2013 Aug;28(8):1027-33. doi: 10.1177/0883073813487598. Epub 2013 May 13. PMID: 23670253; PMCID: PMC3971996.

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Behavioral stress accelerates prostate cancer development in mice.

Hassan S, Karpova Y, Baiz D, Yancey D, Pullikuth A, Flores A, Register T, Cline JM, D'Agostino R Jr, Danial NN, Datta SR, Kulik G. J Clin Invest. 2013 Feb;123(2):874-86. doi: 10.1172/JCI63324. Epub 2013 Jan 25. PMID: 23348742; PMCID: PMC3561807.

 

Inactivation of BAD by IKK inhibits TNFα-induced apoptosis independently of NF-κB activation.

Yan J, Xiang J, Lin Y, Ma J, Zhang J, Zhang H, Sun J, Danial NN, Liu J, Lin A. Cell. 2013 Jan 17;152(1-2):304-15. doi: 10.1016/j.cell.2012.12.021. PMID: 23332762; PMCID: PMC3586589.

 

Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts.

Shah DI, Takahashi-Makise N, Cooney JD, Li L, Schultz IJ, Pierce EL, Narla A, Seguin A, Hattangadi SM, Medlock AE, Langer NB, Dailey TA, Hurst SN, Faccenda D, Wiwczar JM, Heggers SK, Vogin G, Chen W, Chen C, Campagna DR, Brugnara C,
Zhou Y, Ebert BL, Danial NN, Fleming MD, Ward DM, Campanella M, Dailey HA, Kaplan J, Paw BH. Nature. 2012 Nov 22;491(7425):608-12. doi: 10.1038/nature11536. Epub 2012 Nov 7. Erratum in: Nature. 2013 Apr 18;496(7445):386. PMID: 23135403; PMCID: PMC3504625.

 

Metabolic signatures uncover distinct targets in molecular subsets of diffuse large B cell lymphoma.

Caro P, Kishan AU, Norberg E, Stanley IA, Chapuy B, Ficarro SB, Polak K, Tondera D, Gounarides J, Yin H, Zhou F, Green MR, Chen L, Monti S, Marto JA, Shipp MA, Danial NN. Cancer Cell. 2012 Oct 16;22(4):547-60. doi: 10.1016/j.ccr.2012.08.014. PMID: 23079663; PMCID: PMC3479446.

 

Control of tumor bioenergetics and survival stress signaling by mitochondrial HSP90s.

Chae YC, Caino MC, Lisanti S, Ghosh JC, Dohi T, Danial NN, Villanueva J, Ferrero S, Vaira V, Santambrogio L, Bosari S, Languino LR, Herlyn M, Altieri DC. Cancer Cell. 2012 Sep 11;22(3):331-44. doi: 10.1016/j.ccr.2012.07.015. PMID: 22975376; PMCID: PMC3615709.

 

Polysome profiling in liver identifies dynamic regulation of endoplasmic reticulum translatome by obesity and fasting.

Fu S, Fan J, Blanco J, Gimenez-Cassina A, Danial NN, Watkins SM, Hotamisligil GS. PLoS Genet. 2012 Aug;8(8):e1002902. doi: 10.1371/journal.pgen.1002902. Epub 2012 Aug 23. PMID: 22927828; PMCID: PMC3426552.

 

BAD-dependent regulation offuel metabolism and K(ATP) channel activity confers resistance to epileptic seizures.

Giménez-Cassina A, Martínez-François JR, Fisher JK, Szlyk B, Polak K, Wiwczar J, Tanner GR, Lutas A, Yellen G, Danial NN. Neuron. 2012 May 24;74(4):719-30. doi: 10.1016/j.neuron.2012.03.032. PMID: 22632729; PMCID: PMC3361694.

 

BAD modulates counter regulatory responses to hypoglycemia and protective glucoprivic feeding.

Osundiji MA, Godes ML, Evans ML, Danial NN. PLoS One. 2011;6(12):e28016. doi: 10.1371/journal.pone.0028016. Epub 2011 Dec 5. PMID: 22162752; PMCID: PMC3230606.

 

A peptidomics strategy to elucidate the proteolytic pathways that inactivate peptide hormones.

Tinoco AD, Kim YG, Tagore DM, Wiwczar J, Lane WS, Danial NN, Saghatelian A. Biochemistry. 2011 Mar 29;50(12):2213-22. doi: 10.1021/bi2000033. Epub 2011 Feb 22. PMID: 21299233; PMCID: PMC3076939.

 

Noxa: a sweet twist to survival and more.

Gimenez-Cassina A, Danial NN. Mol Cell. 2010 Dec 10;40(5):687-8. doi: 10.1016/j.molcel.2010.11.037. PMID: 21145478.

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Homeostatic functions of BCL-2proteins beyond apoptosis.

Danial NN, Gimenez-Cassina A, Tondera D. Adv Exp Med Biol. 2010;687:1-32. doi: 10.1007/978-1-4419-6706-0_1. PMID: 20919635.

 

Fast kinasedomain-containing protein 3 is a mitochondrial protein essential for cellular respiration.

Simarro M, Gimenez-Cassina A, Kedersha N, Lazaro JB, Adelmant GO, Marto JA, Rhee K, Tisdale S, Danial N, Benarafa C, Orduña A, Anderson P. Biochem Biophys Res Commun. 2010 Oct 22;401(3):440-6. doi: 10.1016/j.bbrc.2010.09.075. Epub 2010 Sep 24. PMID: 20869947; PMCID: PMC2963690.

 

BAD: undertaker by night, candyman by day.

Danial NN. Oncogene. 2008 Dec;27 Suppl 1:S53-70. doi: 10.1038/onc.2009.44. PMID: 19641507.

 

Bad targets the permeability transition pore independent of Bax or Bak to switch betweenCa2+-dependent cell survival and death.

Roy SS, Madesh M, Davies E, Antonsson B, Danial N, Hajnóczky G. Mol Cell. 2009 Feb 13;33(3):377-88. doi:
10.1016/j.molcel.2009.01.018. PMID: 19217411; PMCID: PMC2662194.

 

Transplacental exposure to the vacuolar-ATPase inhibitor bafilomycin disrupts survival signaling in beta cells and delays neonatal remodeling of the endocrine pancreas.

Hettiarachchi KD, Zimmet PZ, Danial NN, Myers MA. Exp Toxicol Pathol. 2008 Aug;60(4-5):295-306. doi: 10.1016/j.etp.2008.02.009. Epub 2008 May 16. PMID: 18486461.

 

Dual role of proapoptotic BAD in insulin secretion and beta cell survival.

Danial NN*, Walensky LD, Zhang CY, Choi CS, Fisher JK, Molina AJ, Datta SR, Pitter KL, Bird GH, Wikstrom JD, Deeney JT, Robertson K, Morash J, Kulkarni A, Neschen S, Kim S, Greenberg ME, Corkey BE, Shirihai OS, Shulman GI, Lowell BB,
Korsmeyer SJ. Nat Med. 2008 Feb;14(2):144-53. doi: 10.1038/nm1717. Epub 2008 Jan 27. PMID: 18223655; PMCID: PMC3918232. *Corresponding Author

 

BCL-2 family proteins: critical checkpoints of apoptotic cell death.

Danial NN. BClin Cancer Res. 2007 Dec 15;13(24):7254-63. doi: 10.1158/1078-0432.CCR-07-1598. PMID: 18094405.

 

Targeting the cell death-survival equation.

Benz EJ Jr, Nathan DG, Amaravadi RK, Danial NN. Clin Cancer Res. 2007 Dec 15;13(24):7250-3. doi: 10.1158/1078-0432.CCR-07-2221. PMID: 18094404.

 

beta-Cell mitochondria exhibit membrane potential heterogeneity that can be altered by stimulatory or toxic fuel levels.

Wikstrom JD, Katzman SM, Mohamed H, Twig G, Graf SA, Heart E, Molina AJ, Corkey BE, de Vargas LM, Danial NN, Collins S, Shirihai OS. Diabetes. 2007 Oct;56(10):2569-78. doi: 10.2337/db06-0757. Epub 2007 Aug 8. PMID: 17686943.

 

Loss of Mcl-1 protein and inhibition of electron transport chain together induce anoxic cell death.

Brunelle JK, Shroff EH, Perlman H, Strasser A, Moraes CT, Flavell RA, Danial NN, Keith B, Thompson CB, Chandel NS. Mol Cell Biol. 2007 Feb;27(4):1222-35. doi: 10.1128/MCB.01535-06. Epub 2006 Dec 4. PMID: 17145774; PMCID: PMC1800715.

 

OPA1 controls apoptotic cristae remodeling independently from mitochondrial fusion.

Frezza C, Cipolat S, Martins de Brito O, Micaroni M, Beznoussenko GV, Rudka T, Bartoli D, Polishuck RS, Danial NN, De Strooper B, Scorrano L. Cell. 2006 Jul 14;126(1):177-89. doi: 10.1016/j.cell.2006.06.025. PMID: 16839885.

 

Cyclophilin D is a component of mitochondrial permeability transition and mediates neuronal cell death after focal cerebral ischemia.

Schinzel AC, Takeuchi O, Huang Z, Fisher JK, Zhou Z, Rubens J, Hetz C, Danial NN, Moskowitz MA, Korsmeyer SJ. Proc Natl Acad Sci U S A. 2005 Aug 23;102(34):12005-10. doi: 10.1073/pnas.0505294102. Epub 2005 Aug 15. PMID: 16103352; PMCID: PMC1189333.

 

v-Abl signaling disrupts SOCS-1 function in transformed pre-B cells.

Limnander A, Danial NN, Rothman PB. Mol Cell. 2004 Aug 13;15(3):329-41. doi: 10.1016/j.molcel.2004.06.041. PMID: 15304214.

 

Cell death: critical control points.

Danial NN, Korsmeyer SJ. Cell. 2004 Jan 23;116(2):205-19. doi: 10.1016/s0092-8674(04)00046-7. PMID: 14744432.

 

BAD and glucokinase reside in a mitochondrial complex that integrates glycolysis and apoptosis.

Danial NN, Gramm CF, Scorrano L, Zhang CY, Krauss S, Ranger AM, Datta SR, Greenberg ME, Licklider LJ, Lowell BB, Gygi SP, Korsmeyer SJ. Nature. 2003 Aug 21;424(6951):952-6. doi: 10.1038/nature01825. PMID: 12931191.

 

Bad-deficient mice develop diffuse large B cell lymphoma.

Ranger AM, Zha J, Harada H, Datta SR, Danial NN, Gilmore AP, Kutok JL, Le Beau MM, Greenberg ME, Korsmeyer SJ. Proc Natl Acad Sci U S A. 2003 Aug 5;100(16):9324-9. doi: 10.1073/pnas.1533446100. Epub 2003 Jul 22. PMID: 12876200; PMCID: PMC170917.

 

Functional involvement of Aktsignaling downstream of Jak1 in v-Abl-induced activation of hematopoietic cells.

Oki S, Limnander A, Danial NN, Rothman PB. Blood. 2002 Aug 1;100(3):966-73. doi: 10.1182/blood.v100.3.966. PMID: 12130510.

 

Positive regulation of interleukin-4-mediated proliferation by the SH2-containing inositol-5'-phosphatase.

Giallourakis C, Kashiwada M, Pan PY, Danial N, Jiang H, Cambier J, Coggeshall KM, Rothman P. J Biol Chem. 2000
Sep 22;275(38):29275-82. doi: 10.1074/jbc.M002853200. PMID: 10875931.

 

JAK-STAT signaling activated by Abl oncogenes.

Danial NN, Rothman P. Oncogene. 2000 May 15;19(21):2523-31. doi: 10.1038/sj.onc.1203484. PMID: 10851051.

 

A thrombopoietin receptor mutant deficient in Jak-STAT activation mediates proliferation but not differentiation in UT-7 cells.

Dorsch M, Danial NN, Rothman PB, Goff SP. Blood. 1999 Oct 15;94(8):2676-85. PMID: 10515871.

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Transcriptional repression of Stat6-dependent interleukin-4-induced genes byBCL-6: specific regulation of iepsilon transcription and immunoglobulin Eswitching.

Harris MB, Chang CC, Berton MT, Danial NN, Zhang J, Kuehner D, Ye BH, Kvatyuk M, Pandolfi PP, Cattoretti G, Dalla-Favera R, Rothman PB. Mol Cell Biol. 1999 Oct;19(10):7264-75. doi: 10.1128/MCB.19.10.7264. PMID: 10490661; PMCID: PMC84719.

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Direct interaction of Jak1 and v-Abl is required for v-Abl-induced activation of STATs and proliferation.

Danial NN, Losman JA, Lu T, Yip N, Krishnan K, Krolewski J, Goff SP, Wang JY, Rothman PB. Mol Cell Biol. 1998 Nov;18(11):6795-804. doi: 10.1128/MCB.18.11.6795. PMID: 9774693; PMCID: PMC109263.

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The thrombopoietin receptor can mediate proliferation without activation of the Jak-STAT pathway.

Dorsch M, Fan PD, Danial NN, Rothman PB, Goff SP. J Exp Med. 1997 Dec 15;186(12):1947-55. doi: 10.1084/jem.186.12.1947. PMID: 9396763; PMCID: PMC2199166.

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Jak-STAT signaling induced by the v-abloncogene.

Danial NN, Pernis A, Rothman PB. Science. 1995 Sep 29; 269(5232):1875-7. doi: 10.1126/science.7569929. PMID: 7569929.