In the News

Massachusetts Life Sciences Center funding to support a Metabolomics Facility at Dana-Farber 
Dana-Farber Cancer Institute

The Massachusetts Life Sciences Center is awarding Dana-Farber Cancer Institute a $1.82 million grant titled, Mass Spectrometry Metabolomics Solutions for Highly Scalable Integrated OMics: Charting Metabolic Contributions to Disease Development and Therapeutic Outcomes. 

A Mitochondrial Power Play in Lymphoma
By Ralph J. DeBerardinis, Cancer Cell Previews

Deregulated energetics is a hallmark of malignancy, but metabolic heterogeneity among individual tumors is unknown. A study by Caro et al. in this issue of Cancer Cell demonstrates that a subset of lymphomas is defined by reliance on mitochondrial energy generation and is selectively killed when this pathway is impaired.

A BAD Portion of Glucose Can be Good for Inflamed Beta Cells
By Christian Frezza, Nature Metabolism News & Views

Exposure to high glucose under inflammatory conditions is detrimental to insulin-secreting beta cells in the pancreas. Fu and colleagues describe a metabolic axis that decreases production of the 'danger molecule’ nitric oxide and improves the survival of beta cells exposed to an inflammatory milieu, thus paving the way to new interventions for diabetes.

PressReleases/
Editorials

A BAD Metabolic Choice
STKE Editor’s choice, Science, Sci. Signal. 5, ec148, 2012. Wong, W. A BAD metabolic choice. Read Article

A BAD Role in Insulin Release
STKE Editors’ choice, Science, Sci. Signal. 1, ec52, 2008. Gough, N.R. A BAD role in insulin release. 
Read Article

Why Cutting Sugar Can Control Seizures: Scientists Identify Metabolic Regulator of Epilepsy Read More
E. Lyons, Cell Press, May 23, 2012

Reverse Engineering Epilepsy’s ‘Miracle’ Diet Read More
RA Leo, Harvard Medical School News & Research, May 23, 2012  

Fatty Diet Preventing Seizures May Lead to Epilepsy Drugs Read More

E. Lopatto, Bloomberg Businessweek, May 23, 2012

Cell Biological Underpinnings of Anti-Epileptic Diet Revealed Read More

A. Breindl, BioWorld, June 8, 2012

Diffuse Large B-Cell Lymphomas are metabolically Heterogeneous 
Cancer Discovery Research Watch

Diffuse large B-cell lymphomas (DLBCL) are aggressive tumors with genetic and clinical variability. DLBCL has been classified into several molecular subgroups based on transcriptional profiling, suggesting that different pathogenic mechanisms and therapeutic targets may exist within this disease. 

When BAD Is Good for ꞵ Cells
By Louis H. Philipson, Cell Metabolism Previews

BAD, a proapoptotic member of the Bcl-2 family of proteins, is regulated by phosphorylation. A recent study (Danial et al., 2008) suggests a phosphorylation-state-dependent bifunctional role of BAD in the regulation of glucose-stimulated insulin secretion and
ꞵ cell mass.

In Epilepsy, BAD Is Not Really Bad
By Luca Scorrano, Neuron

Proper neuronal electrical signaling is crucial for coordinated activity of the brain: when this is malfunctioning, epileptic seizures, defined as a ‘‘transient occurrence of signs and/or symptoms due to abnormal excessive or synchronous neuronal activity in the brain’’ (Fisher et al., 2005), can arise.

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“The true sign of intelligence is not knowledge but imagination.” 

Albert Einstein